MATWIN, a wholly owned subsidiary of Unicancer group (gathering all the French Comprehensive Cancer Centers), is the only national programme dedicated to accelerating early innovation in oncology. Within a few years, this experimental programme that was originally led by the Great South West Canceropole, managed to rally/mobilize an international network of industrial and academic partners severally committed to support innovation in the fight against cancer. Every year, MATWIN offers outreach sessions, training, assessments, coaching and network to optimize oncology French research exposure and attractiveness on a global scale. The whole French ecosystem (major groups, biotechs, canceropoles, TTOs, competitive clusters, incubators, investors, etc.) is involved within MATWIN’s initiative confirming therefore the benefit and added value of this open innovation national action focused on a public health issue.